We include products we think are useful for our readers. If you buy through links on this page, we may earn a small commission Here’s our process.
Medical News Today only shows you brands and products that we stand behind.
Our team thoroughly researches and evaluates the recommendations we make on our site. To establish that the product manufacturers addressed safety and efficacy standards, we:- Evaluate ingredients and composition: Do they have the potential to cause harm?
- Fact-check all health claims: Do they align with the current body of scientific evidence?
- Assess the brand: Does it operate with integrity and adhere to industry best practices?
Is CBD legal?The 2018 Farm Bill removed hemp from the legal definition of marijuana in the Controlled Substances Act. This made some hemp-derived CBD products with less than 0.3% THC federally legal. However, CBD products containing more than 0.3% THC still fall under the legal definition of marijuana, making them federally illegal but legal under some state laws. Be sure to check state laws, especially when traveling. Also, keep in mind that the FDA has not approved nonprescription CBD products, and some products may be inaccurately labeled.
CBD, or cannabidiol, is a chemical compound and one of several cannabinoids present in the cannabis Sativa plant. CBD is available in many forms, including oils. Some of the most potent oils contain up to 12,000 milligrams (mg) of CBD per 30 milliliters (ml).
- Best overall: Zatural Full Spectrum CBD Oil Drops | Skip to Review
- Strongest per serving: CBDMD CBD Oil Tincture Drops | Skip to Review
- Best for quality: Spruce Lab Grade CBD Oil | Skip to Review
- Best for travel: NuLeaf Naturals Full Spectrum Hemp CBD Oil | Skip to Review
- Best organic option: Lazarus Naturals Full Spectrum & High Potency CBD Oil Tincture | Skip to Review
- Best environmentally friendly option: Charlotte’s Web | Skip to Review
- Best flower-only oil: Cornbread Distilled CBD Oil | Skip to review
- Best isolate: Medterra Isolate CBD Oil | Skip to review
CBD has become a popular ingredient in oils, edibles, topicals, and cosmetics. CBD does not cause the “high” typically associated with cannabis use. The cause of the high is another cannabinoid called tetrahydrocannabinol (THC).
People curious about CBD products may wonder about the most potent CBD oil available.
This article provides a list of high potency CBD oils and other CBD products. We also discuss the potential benefits and risks of using strong CBD.
Medical News Today chooses products that meet the following criteria:
- Ingredients: MNT selects products containing safe and high quality clearly labeled ingredients. They should also confirm they are free from pesticides, heavy metals, and mold.
- Dosage: MNT chooses products that must clearly state the CBD dosage.
- Serving size: MNT selects products in which manufacturers recommend a dosage.
- Third-party labs: MNT chooses products that must undergo third-party testing for contaminants by an ISO 17025-compliant laboratory.
- Available certificate of analysis: MNT chooses companies that demonstrate transparency and share a product’s certificate of analysis (COA) after receiving its third-party lab results.
Below are some examples of high-strength CBD oils and tinctures. Oils and tinctures undergo slightly different extraction processes. Manufacturers produce CBD oils by using carbon dioxide to extract CBD. They use alcohol to manufacture tinctures.
Learn more about CBD tinctures.
Please note that this article’s writer has not tried these products, and all the information presented is research-based.
Medical News Today follows a strict product selection and vetting process. Learn more here.
Best overall:
Zatural Full Spectrum CBD Oil Drops
- Price: $27.50–360
- Size: 1, 2, and 4 fluid ounces (fl oz)
- Dosage per bottle: up to 12,000 milligrams (mg)
- Dosage per serving: up to 100 mg
- COA: available online
Zatural Broad Spectrum CBD Oil Drops contain hemp seed oil with no additives or fillers. The oil also contains terpenes, flavonoids, and phytocannabinoids.
This product is available in 1, 2, and 4 fl oz bottles, containing 300–12,000 mg of CBD.
The 12,000 mg option provides a CBD dosage of 100 mg per serving, making it one of the strongest CBD oils in this article.
Pros
- has a short ingredient list, containing only CBD, hemp seed oil, and stevia and essential oils in the peppermint-flavored product
- contains THC, which may contribute to the “entourage effect”
- the company offers a clear dosage calculator based on customer weight
Cons
- more expensive than other options
- not suitable for people who would prefer to avoid THC
- the peppermint flavor is not suitable for people who are sensitive to essential oils
Strongest per serving:
cbdMD CBD Oil Tincture Drops
- Price: $89.99–$209.99
- Size: 1 fl oz
- Dosage per bottle: 1,500–7,500 mg
- Dosage per serving: 50–250 mg
- COA: available online
cbdMD’s CBD Oil Tincture Drops contain 7,500 mg of broad-spectrum CBD per 1 fl oz bottle. The oil provides 250 mg of CBD per serving, the strongest dose in this article.
It contains additional cannabinoids, including cannabinol (CBN) and Cannabigerol (CBG). It is also made with MCT oil.
This CBD oil is vegan and free from THC and gluten.
This tincture comes in natural, mint, orange, or berry flavors.
Use code HEALTHLINE for 20% off all orders.
Pros
- the company claims this product is free from THC, which may appeal to those who prefer to avoid this compound
- has a short ingredient list, containing only hemp extract, MCT oil, and natural flavoring
- available in a variety of flavors
- offers the strongest dose per serving than any other product in this article
Cons
- contains MCT oil, which makes it unsuitable for those allergic to coconut
- bottles with a stronger dose may have a more bitter taste
Best for quality:
Spruce Lab Grade CBD Oil
- Price: $269
- Size: 1 oz
- Dosage per bottle: 2,400 mg
- Dosage per serving: 80 mg
- COA: available online
Spruce’s 2,400 mg full-spectrum CBD Oil delivers 80 mg of full-spectrum CBD per 1 milliliter (ml) dose, equivalent to a full dropper.
The oil is organic and contains no added flavoring. People can choose from two carrier oils: hemp seed oil and MCT oil. The product is also vegan and gluten-free.
This product contains 0.3% THC. The company states that a person taking it might test positive for cannabis, which is unsuitable for people undergoing drug testing.
Use code “MNT” for 15% off and free shipping.
Pros
- people can choose from two carrier oils
- has a short ingredient list, only containing CBD extract and one of the carrier oil options
- made in the United States
Cons
- contains THC, which may make it unsuitable for those who undergo regular drug testing
- may have a bitter taste, as it is a strong dose and does not have any flavorings
Best for travel:
NuLeaf Naturals Full Spectrum Hemp CBD Oil
- Price: $19–249
- Size: 0.17–3.38 fl oz
- Dosage per bottle: 300–6,000 mg
- Dosage per serving: 30 mg
- COA: available online
NuLeaf Naturals offers a full-spectrum CBD oil available in a range of bottle sizes and dosages, from 300-6,000 mg.
The range of bottle sizes may make this product suitable for travel.
The company suggests that people start by using 30 mg or 10 drops each day in two separate doses. They may then increase the dose slowly if needed.
NuLeaf Naturals use full-spectrum CBD and organic virgin hemp seed oil to produce CBD oil products.
The product is unflavored and contains terpenes.
People can also buy a single bottle or buy packs of 3 or 6 bottles.
Pros
- uses organic virgin hemp seed oil
- contains THC, so it may have an entourage effect
- the company uses CO2 extraction, which it claims is a greener alternative
Cons
- contains THC, which makes it unsuitable for those who would prefer not to use this compound or people who have regular drug testing
- not available in any flavors
Best organic option:
Lazarus Naturals Full Spectrum & High Potency CBD Oil Tincture
- Price: $40–120
- Size: 30 or 120 ml
- Dosage per bottle: 1,500 or 6,000 mg
- Dosage per serving: 50 mg
- COA: available online
This full-spectrum oil is available unflavored or in a chocolate mint or strawberry lemonade flavor.
Learn more about Lazarus Naturals.
It is available in sizes of 30 ml or 120 ml. A 30 ml bottle contains 1,500 mg of CBD, whereas a 120 ml contains 6,000 mg of CBD. Each serving of 0.25 ml contains 50 mg of CBD.
This product has USDA Organic and Kosher certifications. Ingredients include organic coconut oil, organic hempseed oil, organic hemp extract, and flavorings.
Lazarus Naturals recommend people start with a 0.25 ml dose, wait for 2 hours, and repeat as necessary.
Pros
- certified organic and Kosher
- the company grows the CBD on its own farms
- available in three flavors: unflavored, chocolate mint, and strawberry lemonade
Cons
- contains MCT oil, which makes it unsuitable for people with a tree nut or coconut allergy
- contains THC, which makes it unsuitable for people who prefer not to use this compound, or those who undergo drug testing
- may not be suitable for people who have been advised not to eat grapefruit by a healthcare professional
Best environmentally friendly option:
Charlotte’s Web Max Strength CBD Oil
- Price: $199.99
- Size: 30 or 100 ml
- Dosage per bottle: 1,800 mg or 6,000 mg
- Dosage per serving: 60 mg
- COA: available online
This 30 ml or 100 ml bottle each contains 60 mg of CBD per 1 ml, making it the highest concentration per ml of CBD the company provides.
Charlotte’s Web says this product is suitable for those who already take CBD and want to steadily increase their CBD dosage in their supplement routine.
This full-spectrum product has a variety of phytocannabinoids, terpenes, and flavonoids. It comes in orange blossom, lemon twist, and mint chocolate flavors.
The company states that the CO2 extraction process it uses is environmentally friendly. It uses carbon dioxide, which the manufacturer claims is safe and clean and has no negative environmental impact.
Pros
- uses a more environmentally friendly extraction process
- may be suitable for those currently taking CBD and looking to increase their dosage
- has a range of flavors
Cons
- contains THC, making it unsuitable for those who undergo regular drug testing or those who prefer not to ingest this compound
- does not have transparent ingredient information, which may make it unsuitable for those with allergies and sensitivities
Best flower-only oil:
Cornbread Distilled CBD Oil
- Price: $39.99–74.96
- Size: 1 fl oz
- Dosage per bottle: 375, 750, or 1,500 mg
- Dosage per serving: 25 or 50 mg
- COA: available online
This full-spectrum CBD oil is available in doses of 25 or 50 mg per 1 ml. Each 1 ml serving also contains either 0.5 or 1 mg of THC.
This oil is only available unflavored. It contains organic hemp flower extract and organic MCT coconut oil. According to the company, it has a smooth and mild flavor.
Cornbread says that only using cannabis flowers increases the amount of cannabinoids and reduces the amount of chlorophyll in the product. The company states that other manufacturers may use stems, leaves, and stalks, which may reduce the quality of the oil.
Pros
- reportedly has a mild flavor
- only uses cannabis flowers, which may increase the amount of cannabinoids a person ingests
- clearly states the amount of THC in each serving
Cons
- contains coconut oil, making it unsuitable for those with a tree nut or coconut allergy
- contains THC, which some people may prefer to avoid
Best isolate:
Medterra Isolate CBD Oil
- Price: $39.99–199.99
- Size: 1 fl oz
- Dosage per bottle: 500, 1,000, 3,000, or 6,000 mg
- Dosage per serving: 16, 33, or 100 mg
- COA: available online
This oil contains CBD isolate and MCT oil. CBD isolate means that the product does not contain any THC. Each 1 ml serving provides 16, 33, or 100 mg of CBD, depending on the strength a person purchases.
Medterra states that this oil may be a suitable option for those who undergo drug testing, as CBD isolate does not contain THC.
This oil is non-GMO and made in the U.S.
Medterra recommends using one dropper one or more times per day.
Pros
- has a short ingredient list of hemp extract and MCT oil
- does not contain THC, making it a good option for people who prefer to avoid this compound
- as it does not contain THC, it may be suitable for day and night use
Cons
- contains MCT oil, making it unsuitable for people with a tree nut or coconut allergy
- no flavors available
The table below provides a quick comparison of the strongest CBD oils in this article:
| Price | Size | Dosage per bottle | Dosage per serving | |
|---|---|---|---|---|
| Zatural | $27.50–360 | 1, 2, and 4 fl oz | 12,000 mg | 100 mg |
| CBDMD | $89.99–209.99 | 1 fl oz | 7,500 mg | 250 mg |
| Spruce | $269 | 1 oz | 2,400 mg | 80 mg |
| NuLeaf | $19–249 | 0.17-3.38 fl oz | 300–6,000 mg | 30 mg |
| Lazarus Naturals | $40–120 | 30 or 120 ml | 1,500 mg or 6000 mg | 50 mg |
| Charlotte’s Web | $199.99 | 30 or 100 ml | 1,800 mg or 6000 mg | 60 mg |
| Cornbread | $39.99–74.96 | 1 fl oz | 375, 750, or 1,500 mg | 25 or 50 mg |
| Medterra | $39.99–199.99 | 1 fl oz | 500, 1,000, 3,000, or 6,000 mg | 16, 33, or 100 mg |
A person interested in trying CBD oil should research different products to find one that is safe and reliable. Customer reviews from third-party sites such as the Better Business Bureau and Trustpilot are useful tools when researching brands.
A person may want to review each product’s ingredient list and concentration levels. They might want to know if the product is lab-grade and third-party tested.
A person using CBD for the first time may find a product with a lower dosage more suitable. They can then gradually increase the dosage as desired.
According to
People should also not use CBD alongside sedative drugs, such as barbiturates, and narcotics, such as codeine and morphine. Anybody taking medication should speak with a doctor prior to taking CBD.
CBD can make people drowsy, so people should avoid driving and handling heavy machinery when taking this product.
A person taking CBD for the first time should avoid strong CBD. It is better to start with a lower dose and increase the dosage slowly.
A person should always speak with a healthcare professional before using CBD products.
While there is a wealth of research regarding the effects of cannabis and THC, there are few high quality human trials investigating CBD alone.
It is difficult for experts to predict precisely how differences in strength impact CBD’s effectiveness.
Based on the findings of a
Most of the studies included in this review evaluated daily doses of 300–600 mg of CBD, but a few studies reported using doses as high as 2,000 mg per day.
Everyone responds differently to CBD, so it is best for people using CBD for the first time to start at a lower dose.
Purchasing a higher CBD concentration product may be more cost-effective and convenient for some people.
For example, someone who uses 300 mg of CBD for chronic pain or anxiety would use 12 full droppers of 25 mg of CBD oil. They could get a similar 300 mg dose by using only one and a half droppers of 2,000 mg CBD oil.
However, stronger products may provide more CBD per unit but may lead to inaccurate dosing.
CBD
However, the
- drowsiness
- gastrointestinal problems
- diarrhea
- decreased appetite
- mood changes, such as irritability
- liver injury (with certain drug interactions)
- interactions with alcohol and other drugs
The FDA has approved only one CBD product called
Learn more about the side effects of CBD here.
Label accuracy
People should avoid purchasing products from companies that have inaccurate labeling. The FDA has
In a recent study, researchers found that nearly half of the 80 CBD products it looked at that were available for sale in central Kentucky had inaccurate label information.
However, most reputable CBD manufacturers will provide third-party lab results to their customers.
People should always use caution when shopping for CBD, especially high potency products. High potency CBD products can be inaccurately labeled. Some products may not even contain CBD.
Additionally, some CBD products may contain enough THC to produce a positive result in a drug test.
A person should always speak with their healthcare professional before trying any supplement, including CBD oil, especially if they are currently taking medications.
Research suggests that CBD
Below are some of the most commonly asked questions about CBD oils.
When is the best time to take CBD oil?
There is no best time to take CBD oil. Some companies suggest people take doses of their CBD oil products more than once during the day. However, some people may find that CBD oil makes them drowsy, making it suitable for bedtime use.
Is it safe to take CBD oil daily?
Current research has not indicated any negative effects of taking CBD oil daily. Additionally, many companies that manufacture these products recommend that people take a daily dose of CBD oil.
How do I determine what dose of CBD oil is best for me?
People taking CBD oil who feel they may benefit from taking more can slowly increase their dosage and gauge the results. Those who have never used CBD oil should start with a lower dose and gradually work up to a stronger dose.
CBD is a popular product. Current preliminary research suggests CBD may be beneficial for treating various conditions, including epilepsy, anxiety, and some forms of chronic pain.
Learn more about the potential benefits of CBD oil.
However, more high quality, controlled trials are needed to verify the medical applications of CBD.
People who currently use CBD products but feel they may benefit from stronger alternatives can use this article for guidance. People who have never used CBD but are interested in trying it should start with a low dose and gradually work up to more potent products.
People should also discuss CBD with a doctor, as it might interact with medications and supplements.
Learn more about cannabinoids and possible drug interactions.