Endometrial cancer starts in the layer of cells that form the lining of the womb, called the endometrium. It is a cancer of the womb, or uterus.
Most uterine cancers start as endometrial cancer. Another type of cancer, uterine sarcoma,
Uterine cancer is the
Early symptoms
Endometrial cancer can also cause pain in the pelvic area, less commonly during sexual intercourse. Some people also experience pain when urinating or difficulty emptying the bladder.
As the cancer progresses, there may be:
- a feeling of a mass or heaviness in the pelvic area
- unintended weight loss
- fatigue
- nausea
- pain in several parts of the body, including the legs, back, and pelvic area
These symptoms can also stem from other, noncancerous health problems, such as fibroids, endometriosis, endometrial hyperplasia, and polyps in the uterine lining.
It is important to rule out endometrial cancer if another condition is causing similar symptoms.
If tests detect cancer, the doctor will assess the grade of the tumor to see how rapidly the cells are dividing and how quickly the cancer is likely to grow.
A higher-grade tumor is more likely to grow quickly and spread to other parts of the body.
The best course of treatment depends, in part, on the stage, or how far the cancer has spread.
Doctors may use the following definitions when staging endometrial cancer:
- Stage 0: Cancerous cells remain where they started, on the surface of the inner lining of the uterus.
- Stage 1: The cancer has spread through the inner lining of the uterus to the endometrium and possibly to the myometrium — the middle layer of the uterine wall.
- Stage 2: The tumor has spread to the cervix.
- Stage 3: The tumor has spread through the uterus to nearby tissue, including the vagina or a lymph node.
- Stage 4: The cancer has spread to the bladder or an intestine, and possibly to other areas, such as the bones, liver, or lungs.
Learn more about how doctors diagnose and stage cancer.
When endometrial cancer spreads from the endometrium to other parts of the body, doctors say that it has “metastasized.”
Below, find an interactive 3D map of the stages of endometrial cancer. Explore it using the mousepad or touchscreen.
Doctors do not know what causes endometrial cancer.
Cancer occurs when genetic changes cause cells to start growing uncontrollably instead of dying at the expected stage of their life cycles.
Research into the cause of these genetic changes is ongoing, but health experts know that
People
The risk is greater for those who:
- have never been pregnant
- start menstruating before 12 years of age
- experience menopause after 55 years of age
Other factors include:
- using estrogen-only hormone therapy after menopause
- using Nolvadex to prevent or treat breast cancer
- having had previous radiation therapy to the pelvis
- having a family history of uterine cancer
- having polycystic ovary syndrome, or PCOS
- having diabetes, obesity, hypertension, or other aspects of metabolic syndrome
- having endometrial hyperplasia
It is important to recognize the early signs of endometrial cancer because prompt treatment can significantly improve the outlook.
Early signs include:
- vaginal bleeding between periods
- periods that are heavier than usual
- vaginal bleeding after menopause
- unusual vaginal discharge that is watery or tinged with blood
Anyone who has unusual discharge or periods should consult a doctor.
To diagnose this type of cancer, a physician will:
- review the symptoms
- ask about personal and family medical histories
- perform a pelvic examination
- request some tests, if they believe that it is necessary
The doctor will inspect and feel the cervix, uterus, vagina, and labia to detect any lumps or changes in shape or size.
With a transvaginal ultrasound, a doctor can assess the size and shape of the uterus and the texture and thickness of the endometrium and rule out other conditions.
To perform this scan, a healthcare professional inserts a transducer into the vagina and assesses the relayed images on a monitor.
Blood tests can also reveal the presence of cancerous cells.
Alternately, a doctor may use hysteroscopy, which involves inserting a thin scope into the vagina and uterus.
Or, they may take an aspiration biopsy, using a small, flexible tube to take sample cells for examination under a microscope.
To monitor the progress of endometrial cancer, a doctor may use:
The average 5-year survival rate for endometrial cancer overall is around
To reduce the risk, the